One of the biggest points of confusion for people new to Blender seems to be navigating the UI. The UI layout of Blender is amazingly powerful but it is extremely easy to find yourself lost in a sea of windows and panels you’ve opened with no idea how to close them. This video tutorial shows you how to customize the Blender layout exactly how you want it and once you get the gist of it, it is an extremely powerful system. The video is for Blender 2.59, but should be equally valid in 2.6x.
There is no audio, it is entirely narrated on screen. The video is probably illegible in the embedded window above, however it was encoded at 1080p and hosted on YouTube and Vimeo in HD ( although for some reason the Vimeo encoding looks much worse, so use YouTube for the best quality ).
If you are just starting out with Blender, I highly suggest you check it out. Once you realize just how much flexibility you have in deciding how you want to work you will become much more productive. Oh and if you are lucky enough to have multiple monitors, Blender is amazingly flexible in this regard too!